Back to Search
Start Over
Anti-amnesic and anti-cholinesterase activities of α-asarone against scopolamine-induced memory impairments in rats.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2022 Sep; Vol. 26 (17), pp. 6344-6350. - Publication Year :
- 2022
-
Abstract
- Objective: Alzheimer's disease (AD) is a neurological ailment that causes memory loss and impairments and is linked to a drop-in acetylcholine level. Acetylcholinesterase (AChE) inhibitors are used for the management of AD. In our ongoing research to search for natural AChE inhibitors from medicinal plants, we found that the Acorus calamus possesses memory-enhancing properties. α-Asarone is the major compound isolated from the Acorus calamus and it has neuroprotective action in animal models, nonetheless, its anticholinesterase activity in different brain regions was not fully understood. The purpose of this research was to determine the anti-amnesic and anti-cholinesterase activities of α-asarone against scopolamine-induced memory impairments in rats.<br />Materials and Methods: The anti-cholinesterase activity of α-asarone was determined using Ellman's method in different brain areas, such as the cortex, hippocampus, and striatum. In addition, the anti-amnesic effect of α-asarone was also investigated using elevated plus-maze, passive avoidance, and active avoidance tests.<br />Results: The effect of α-asarone on memory impairment against scopolamine-induced (1 mg/kg body weight) amnesia was evaluated. Administration of α-asarone (15 and 30 mg/kg body weight) for 14 days to rats significantly ameliorated the scopolamine-induced memory impairment as measured in the elevated plus-maze, passive avoidance, and avoidance active tests compared to the scopolamine-treated group. In this study, we also show that α-asarone treatment significantly (p<0.05) reduced brain acetylcholinesterase activity in the cortex, hippocampus, and striatum brain regions of amnesic rats.<br />Conclusions: These results confirmed that α-asarone has anti-amnesic and anti-cholinesterase potential which may be useful for the management of AD.
- Subjects :
- Acetylcholine metabolism
Acetylcholinesterase metabolism
Animals
Avoidance Learning
Body Weight
Maze Learning
Rats
Allylbenzene Derivatives pharmacology
Alzheimer Disease chemically induced
Alzheimer Disease drug therapy
Amnesia chemically induced
Amnesia drug therapy
Anisoles pharmacology
Cholinesterase Inhibitors pharmacology
Memory Disorders chemically induced
Memory Disorders drug therapy
Scopolamine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 26
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 36111936
- Full Text :
- https://doi.org/10.26355/eurrev_202209_29660