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SARS-CoV-2 Infection in Patients Treated with Azacitidine and Venetoclax for Acute Leukemia: A Report of a Case Series Treated in a Single Institution.
- Source :
-
Chemotherapy [Chemotherapy] 2023; Vol. 68 (1), pp. 16-22. Date of Electronic Publication: 2022 Sep 14. - Publication Year :
- 2023
-
Abstract
- Introduction: Venetoclax combined with azacitidine (AZA-VEN) constitutes an option for the treatment of acute myeloid leukemia. There are, however, no data on the COVID-19 incidence and outcome in patients treated with AZA-VEN.<br />Methods: Patients with acute leukemia treated with AZA-VEN at a single institution were included in this prospective observational study.<br />Results: Thirteen patients were enrolled, 46% with treatment-naïve, and 56% with relapsed/refractory disease. Fifty-four percent of patients were males; the median age was 69 years. Six patients (46%) developed COVID-19 during the observation time. The median time to COVID-19 was 24 days from the initiation of AZA-VEN. The 2-month cumulative incidence of COVID-19 was 46.2%. Two patients (33%) succumbed to COVID-19. The 100-day COVID-19-free survival from AZA-VEN initiation was 61%. The median follow-up time was 4.3 months.<br />Discussion/conclusion: COVID-19 constitutes a frequent complication of AZA-VEN treatment in the era of the COVID-19 pandemic, leading to death in a significant proportion of patients.<br /> (© 2022 S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 1421-9794
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 36103840
- Full Text :
- https://doi.org/10.1159/000527010