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Definitive antibiotic treatment with a third-generation cephalosporin and with piperacillin-tazobactam worked well for some children with Serratia bacteraemia.
- Source :
-
Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2022 Dec; Vol. 111 (12), pp. 2369-2377. Date of Electronic Publication: 2022 Sep 23. - Publication Year :
- 2022
-
Abstract
- Aim: This study aimed to describe epidemiological and clinical characteristics of Serratia bacteraemia and to identify factors associated with mortality.<br />Methods: The microbiology database of Schneider Children's Medical Centre of Israel was examined for Serratia marcescens positive blood cultures, between January 2007 and May 2020. Demographic, clinical and microbial characteristics were analysed.<br />Results: Of the 81 patients files that met the inclusion criteria, 64 (80%) were of patients hospitalised in paediatric intensive care units. The median age was 78 days and 54% were male. In-hospitalisation mortality was 26%, 62% died under 90 days old. Underlying conditions including prematurity, congenital cardiac defects and malignancies were noted in 95% of patients. Prior to the bloodstream infections, 62% of patients underwent procedures, 64% were on ventilatory support and 77% had central lines. Thrombocytopenia and elevated C-reactive protein levels were found in 60% of the children. Twenty-eight children received definitive monotherapy as either piperacillin-tazobactam or a third-generation cephalosporin; survival rates were similar between the two antibiotic treatment groups.<br />Conclusion: In our cohort, 26% died. Death was more common in young infants. Mortality was associated with hospitalisation in intensive care units and thrombocytopenia. Survival rates following definitive monotherapy were similar for patients treated with piperacillin-tazobactam and those treated with third-generation cephalosporin.<br /> (© 2022 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
- Subjects :
- Child
Humans
Male
Aged
Female
Anti-Bacterial Agents therapeutic use
Piperacillin adverse effects
Penicillanic Acid adverse effects
Serratia
Piperacillin, Tazobactam Drug Combination therapeutic use
Cephalosporins therapeutic use
Bacteremia drug therapy
Bacteremia microbiology
Thrombocytopenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2227
- Volume :
- 111
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Acta paediatrica (Oslo, Norway : 1992)
- Publication Type :
- Academic Journal
- Accession number :
- 36103246
- Full Text :
- https://doi.org/10.1111/apa.16542