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Kaempferol and atherosclerosis: From mechanism to medicine.
- Source :
-
Critical reviews in food science and nutrition [Crit Rev Food Sci Nutr] 2024; Vol. 64 (8), pp. 2157-2175. Date of Electronic Publication: 2022 Sep 13. - Publication Year :
- 2024
-
Abstract
- Natural products possess pleiotropic cardiovascular protective effects owing to their anti-oxidation, anti-inflammation and anti-thrombotic properties. Kaempferol, (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), is a kind of naturally occurring flavonoid existing in many common fruits and vegetables (e.g., onions, broccoli, strawberries and grapes) and particularly in traditional Chinese medicine as exemplified by Ginkgo biloba . Epidemiological, preclinical and clinical studies have revealed an inverse association between the consumption of kaempferol-containing foods and medicines and the risk of developing cardiovascular diseases. Numerous translational studies in experimental animal models and cultured cells have demonstrated a wide range of pharmacological activities of kaempferol. In this article, we reviewed the antioxidant, anti-inflammatory and cardio-protective activities of kaempferol and elucidated the potential molecular basis of the therapeutic capacity of kaempferol by focusing on its anti-atherosclerotic effects. Overall, the review presents the health benefits of kaempferol-containing plants and medicines and reflects on the potential of kaempferol as a possible drug candidate to prevent and treat atherosclerosis, the underlying pathology of most cardiovascular diseases.
Details
- Language :
- English
- ISSN :
- 1549-7852
- Volume :
- 64
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Critical reviews in food science and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 36099317
- Full Text :
- https://doi.org/10.1080/10408398.2022.2121261