Basal ganglia engagement during REM sleep movements in Parkinson's disease.

Authors :: Verma AK
Acosta Lenis SF
Aman JE
Sanabria DE
Wang J
Pearson A
Hill M
Patriat R
Schrock LE
Cooper SE
Park MC
Harel N
Howell MJ
MacKinnon CD
Vitek JL
Johnson LA
Source :: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2022 Sep 12; Vol. 8 (1), pp. 116. Date of Electronic Publication: 2022 Sep 12.
Publication Year :: 2022
Abstract: To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.<br /> (© 2022. The Author(s).)