Clinicopathologic Features and Treatment of CD10-Positive Mantle Cell Lymphoma: A Case Report and Review of Literature.

Mantle cell lymphoma (MCL) is a rare and aggressive non-Hodgkin's B cell lymphoma characterized by the translocation t(11;14) (q13;32) and overexpression of CCND1 . MCL is immunophenotypically identified as CD20 ⁺ , CD5 ⁺ , CyclinD1+, CD43 ⁺ , CD10 ^- , BCL6 ^- , and CD23 ^- . It is often distinguished from B cell lymphomas of germinal center cell origin by the absence of CD10 expression. Here we report the unique clinicopathologic features of a patient with CD10 ⁺ MCL with gastrointestinal involvement and review current literature identifying this unique immunophenotype.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Hino, Pham, Gray, Wang, Castillo, Akhtari and Liu.)