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Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis -infected patients with cutaneous leishmaniasis.
- Source :
-
Frontiers in immunology [Front Immunol] 2022 Aug 25; Vol. 13, pp. 974051. Date of Electronic Publication: 2022 Aug 25 (Print Publication: 2022). - Publication Year :
- 2022
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Abstract
- The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania , the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severity. A comparison of systemic immune profiles in patients with cutaneous leishmaniasis caused by L. guyanensis and healthy individuals with the same socio-epidemiological characteristics coming from the same endemic areas as the patients is performed to identify particular immune profile and pathways associated with the progression of disease development. Twenty-seven plasma soluble circulating factors were evaluated between the groups by univariate and multivariate analysis. The following biomarkers pairs IL-17/IL-9 (ρ=0,829), IL-17/IL-12 (ρ=0,786), IL-6/IL-1ra (ρ=0,785), IL-6/IL-12 (ρ=0,780), IL-1β/G-CSF (ρ=0,758) and IL-17/MIP-1β (ρ=0,754) showed the highest correlation mean among the patient while only INF-γ/IL-4 (ρ=0.740), 17/MIP-1β (ρ=0,712) and IL-17/IL-9 (ρ=0,707) exhibited positive correlation among the control group. The cytokine IL-17 and IL1β presented the greater number of positive pair correlation among the patients. The linear combinations of biomarkers displayed IP-10, IL-2 and RANTES as the variables with the higher discriminatory activity in the patient group compared to PDGF, IL-1ra and eotaxin among the control subjects. IP-10, IL-2, IL-1β, RANTES and IL-17 seem to be predictive value of progression to the development of disease among the Lg -infected individuals.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Mesquita, Junior, Silva, Silva, Araújo, Pinheiro, Kerr, Silva, Souza, Almeida, Queiroz, Souza, Silva, Sequera, Souza, Barbosa, Pontes, Guerra and Ramasawmy.)
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 36091007
- Full Text :
- https://doi.org/10.3389/fimmu.2022.974051