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Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8 + T cells.
- Source :
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EBioMedicine [EBioMedicine] 2022 Oct; Vol. 84, pp. 104253. Date of Electronic Publication: 2022 Sep 08. - Publication Year :
- 2022
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Abstract
- Background: Harnessing CD8 <superscript>+</superscript> T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8 <superscript>+</superscript> T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the extent of this recovery under long-term ART is less understood.<br />Methods: We analyzed the differentiation status and function of HIV-specific CD8 <superscript>+</superscript> T cells after long-term ART initiated in acute or chronic HIV infection ex vivo and upon in vitro recall.<br />Findings: ART initiation in any stage of acute HIV infection promoted the persistence of long-lived HIV-specific CD8 <superscript>+</superscript> T cells with high expansion (P<0·0008) and cytotoxic capacity (P=0·02) after in vitro recall, albeit at low cell number (P=0·003). This superior expansion capacity correlated with stemness (r=0·90, P=0·006), measured by TCF-1 expression, similar to functional HIV-specific CD8 <superscript>+</superscript> T cells found in spontaneous controllers. Importanly, TCF-1 expression in these cells was associated with longer time to viral rebound ranging from 13 to 48 days after ART interruption (r =0·71, P=0·03). In contrast, ART initiation in chronic HIV infection led to more differentiated HIV-specific CD8 <superscript>+</superscript> T cells lacking stemness properties and exhibiting residual dysfunction upon recall, with reduced proliferation and cytolytic activity.<br />Interpretation: ART initiation in acute HIV infection preserves functional HIV-specific CD8 <superscript>+</superscript> T cells, albeit at numbers too low to control viral rebound post-ART. HIV remission strategies may need to boost HIV-specific CD8 <superscript>+</superscript> T cell numbers and induce stem cell-like properties to reverse the residual dysfunction persisting on ART in people treated after acute infection prior to ART release.<br />Funding: U.S. National Institutes of Health and U.S. Department of Defense.<br />Competing Interests: Declaration of interests All the other authors declare that they have no competing interests.<br /> (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2352-3964
- Volume :
- 84
- Database :
- MEDLINE
- Journal :
- EBioMedicine
- Publication Type :
- Academic Journal
- Accession number :
- 36088683
- Full Text :
- https://doi.org/10.1016/j.ebiom.2022.104253