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Does treatment delay for blunt cerebrovascular injury affect stroke rate?: An EAST multicenter study.

Authors :
Appelbaum RD
Esposito E
Spaulding MC
Simpson JP
Dunn J
Zier LB
Burruss S
Kim PP
Jacobson LE
Williams JM
Nahmias J
Grigorian A
Harmon L
Gergen AK
Chatoor M
Rattan R
Young AJ
Pascual JL
Murry J
Ong AW
Muller A
Sandhu RS
Bugaev N
Tatar A
Zreik K
Lieser MJ
Stein DM
Scalea TM
Lauerman MH
Source :
Injury [Injury] 2022 Nov; Vol. 53 (11), pp. 3702-3708. Date of Electronic Publication: 2022 Aug 18.
Publication Year :
2022

Abstract

Background: The purpose of this study was to analyze injury characteristics and stroke rates between blunt cerebrovascular injury (BCVI) with delayed vs non-delayed medical therapy. We hypothesized there would be increased stroke formation with delayed medical therapy.<br />Methods: This is a sub-analysis of a 16 center, prospective, observational trial on BCVI. Delayed medial therapy was defined as initiation >24 hours after admission. BCVI which did not receive medical therapy were excluded. Subgroups for injury presence were created using Abbreviated Injury Scale (AIS) score >0 for AIS categories.<br />Results: 636 BCVI were included. Median time to first medical therapy was 62 hours in the delayed group and 11 hours in the non-delayed group (p < 0.001). The injury severity score (ISS) was greater in the delayed group (24.0 vs the non-delayed group 22.0, p <  0.001) as was the median AIS head score (2.0 vs 1.0, p <  0.001). The overall stroke rate was not different between the delayed vs non-delayed groups respectively (9.7% vs 9.5%, p = 1.00). Further evaluation of carotid vs vertebral artery injury showed no difference in stroke rate, 13.6% and 13.2%, p = 1.00 vs 7.3% and 6.5%, p = 0.84. Additionally, within all AIS categories there was no difference in stroke rate between delayed and non-delayed medical therapy (all N.S.), with AIS head >0 13.8% vs 9.2%, p = 0.20 and AIS spine >0 11.0% vs 9.3%, p = 0.63 respectively.<br />Conclusions: Modern BCVI therapy is administered early. BCVI with delayed therapy were more severely injured. However, a higher stroke rate was not seen with delayed therapy, even for BCVI with head or spine injuries. This data suggests with competing injuries or other clinical concerns there is not an increased stroke rate with necessary delays of medical treatment for BCVI.<br />Competing Interests: Conflict of interest None.<br /> (Copyright © 2022. Published by Elsevier Ltd.)

Details

Language :
English
ISSN :
1879-0267
Volume :
53
Issue :
11
Database :
MEDLINE
Journal :
Injury
Publication Type :
Academic Journal
Accession number :
36085175
Full Text :
https://doi.org/10.1016/j.injury.2022.08.043