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A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence.

Authors :
Toraih EA
Fawzy MS
Ning B
Zerfaoui M
Errami Y
Ruiz EM
Hussein MH
Haidari M
Bratton M
Tortelote GG
Hilliard S
Nilubol N
Russell JO
Shama MA
El-Dahr SS
Moroz K
Hu T
Kandil E
Source :
Cancers [Cancers (Basel)] 2022 Aug 26; Vol. 14 (17). Date of Electronic Publication: 2022 Aug 26.
Publication Year :
2022

Abstract

Papillary thyroid carcinomas (PTCs) account for most endocrine tumors; however, screening and diagnosing the recurrence of PTC remains a clinical challenge. Using microRNA sequencing (miR-seq) to explore miRNA expression profiles in PTC tissues and adjacent normal tissues, we aimed to determine which miRNAs may be associated with PTC recurrence and metastasis. Public databases such as TCGA and GEO were utilized for data sourcing and external validation, respectively, and miR-seq results were validated using quantitative real-time PCR (qRT-PCR). We found miR-145 to be significantly downregulated in tumor tissues and blood. Deregulation was significantly related to clinicopathological features of PTC patients including tumor size, lymph node metastasis, TNM stage, and recurrence. In silico data analysis showed that miR-145 can negatively regulate multiple genes in the TC signaling pathway and was associated with cell apoptosis, proliferation, stem cell differentiation, angiogenesis, and metastasis. Taken together, the current study suggests that miR-145 may be a biomarker for PTC recurrence. Further mechanistic studies are required to uncover its cellular roles in this regard.

Details

Language :
English
ISSN :
2072-6694
Volume :
14
Issue :
17
Database :
MEDLINE
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
36077665
Full Text :
https://doi.org/10.3390/cancers14174128