Pilot Tone-Triggered MRI for Quantitative Assessment of Cardiac Function, Motion, and Structure.

Objective: The aim of this study was to test the hypothesis that there are good agreements between cardiac functional and structural indices derived from magnetic resonance imaging (MRI) sequences triggered with pilot tone (PT) and electrocardiogram (ECG).
Materials and Methods: Sixteen healthy volunteers (11 male, age 21-76 years) underwent a cardiac MRI scan. Cine MRI, T1, and T2 mapping were acquired by using PT and ECG triggering. Quantitative measurements, including left and right ventricular end-diastolic volume, end-systolic volume, stroke volume, ejection fraction, longitudinal strain, left ventricular T1 and T2 values, left and right atrial longitudinal strain, and maximal/minimal volumes, were measured. The interclass correlation coefficient, coefficient of variation, and Bland-Altman plots were used to evaluate the agreements between measurements derived by MRI sequences triggered with 2 methods.
Results: There were no significant differences among end-diastolic volume, end-systolic volume, stroke volume, ejection fraction, left ventricle mass, T1 and T2 values, or longitudinal strains acquired using PT and ECG. There were good agreements and low variations between the levels of these indices acquired with PT and ECG. Interclass correlation coefficients mainly ranged from 0.73 to 0.98. The coefficients of variation ranged from 1.4% to 22.6%.
Conclusions: Pilot tone-triggered MRI provides comparable measurements of cardiac function, motion, and structure as ECG-triggered MRI. Pilot tone has the potential to become a backup of ECG gating in cardiovascular imaging.
Competing Interests: Conflicts of interest and sources of funding: This study was supported by a grant from the National Institutes of Health (R01HL117888). J.C.C. has disclosures for Siemens (research grant to institution, advisory board), Bayer (research grant to institution, advisory board, speaker), Bracco (advisory board), Guerbet (research grant to institution); P.S. and C.H. are full-time employees of Siemens Healthcare GmbH. R.D. is a full-time employee of Siemens Medical Solutions USA. All other authors have no other disclosure.
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