Back to Search Start Over

Is histopathological synovitis score a predictor of postoperative requirement for additional or alternative drug treatment in the patients with rheumatoid arthritis?

Authors :
Koyama K
Wako M
Ohba T
Nakagomi D
Koizumi R
Haro H
Source :
Modern rheumatology [Mod Rheumatol] 2023 Aug 25; Vol. 33 (5), pp. 906-910.
Publication Year :
2023

Abstract

Objectives: Histopathological synovitis scoring is useful for assessing activity in patients with rheumatoid arthritis (RA) at sampling, but it is unclear whether it can be a predictor of future drug treatment. The purpose of this study was to examine whether histopathological synovitis score is a predictor of postoperative requirement for additional or alternative drug treatment after total knee arthroplasty (TKA).<br />Methods: Thirty patients with RA in whom synovial samples were obtained during TKA were included. Patients were divided into the drug treatment enhanced group (EG), which included patients who needed additional or alternative drug treatment within 1 year after TKA, and the drug treatment maintenance group (MG). The Rooney synovitis score (RSS) was compared between groups. Logistic regression analysis was performed to clarify prognostic factors for postoperative drug treatment change.<br />Results: The total RSS was significantly higher in the EG than in the MG (29.3 vs 15.1; P < .001). Multivariate analysis showed that total RSS and swollen joint counts were independent variable associated with postoperative requirement for additional or alternative drug treatment (P < .05).<br />Conclusions: Histopathological synovitis scoring may predict requirement for additional or alternative drug treatment in patients with RA after TKA.<br /> (© Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1439-7609
Volume :
33
Issue :
5
Database :
MEDLINE
Journal :
Modern rheumatology
Publication Type :
Academic Journal
Accession number :
36069644
Full Text :
https://doi.org/10.1093/mr/roac108