Back to Search
Start Over
Dietary carbohydrate type and cholesterol-induced hypercholesterolemia in cynomolgus monkeys: influence of oral antibiotic.
- Source :
-
Biochemical medicine and metabolic biology [Biochem Med Metab Biol] 1987 Jun; Vol. 37 (3), pp. 295-306. - Publication Year :
- 1987
-
Abstract
- The relationship of carbohydrate type to cholesterol-induced hypercholesterolemia and the potential role of intestinal flora in the above process were examined in 12 male cynomolgus monkeys (M. fascicularis). Semipurified diets provided two types of carbohydrates (starch or sucrose, 49% by calorie) with 0.4 mg cholesterol/kcal. Six weeks of the starch diet resulted in significantly enhanced hypercholesterolemia when compared to sucrose diet. Starch in relation to sucrose produced cholesterol enrichment of intermediate density lipoproteins and increase in low density lipoprotein particles, whereas sucrose increased high density lipoprotein constituents (phospholipids, cholesterol, and apoA-I) and triglyceride content of very low density lipoproteins. Fecal Escherichia counts were high during the starch diet as contrasted with sucrose diet, but the Escherichia, Streptococcus, and Bacteroides groups did not show differences by diet following each consecutive 4-week period of oral neomycin (107 mg/kg body wt) treatment and withdrawal. The magnitude of hypercholesterolemia during these periods also remained similar between starch and sucrose, suggesting formation of germfree metabolic characteristics. Thus, the magnitude of cholesterol-induced hypercholesterolemia can be affected by the type of carbohydrate, which may be in part determined by intestinal flora metabolism.
- Subjects :
- Animals
Bacteroides isolation & purification
Cholesterol blood
Escherichia isolation & purification
Feces microbiology
Lactobacillus isolation & purification
Lipoproteins blood
Macaca fascicularis
Male
Streptococcus isolation & purification
Triglycerides blood
Cholesterol, Dietary
Dietary Carbohydrates pharmacology
Hypercholesterolemia blood
Lipids blood
Neomycin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0885-4505
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical medicine and metabolic biology
- Publication Type :
- Academic Journal
- Accession number :
- 3606891
- Full Text :
- https://doi.org/10.1016/0885-4505(87)90040-5