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Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria.
- Source :
-
Malaria journal [Malar J] 2022 Sep 06; Vol. 21 (1), pp. 255. Date of Electronic Publication: 2022 Sep 06. - Publication Year :
- 2022
-
Abstract
- Background: Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.<br />Methods: Using flow-cytometry, circulating polymorphonuclear-MDSC were evaluated in cryopreserved samples from patients with uncomplicated Plasmodium vivax (n = 8) and uncomplicated (n = 4) and severe (n = 16) falciparum malaria from Papua, Indonesia.<br />Results: The absolute number of circulating polymorphonuclear-MDSC were significantly elevated in severe falciparum malaria patients compared to controls (n = 10). Polymorphonuclear-MDSC levels in uncomplicated vivax malaria were also elevated to levels comparable to that seen in severe falciparum malaria.<br />Conclusion: Control of expansion of immunosuppressive MDSC may be important for development of effective immune responses in falciparum and vivax malaria.<br /> (© 2022. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1475-2875
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Malaria journal
- Publication Type :
- Academic Journal
- Accession number :
- 36068577
- Full Text :
- https://doi.org/10.1186/s12936-022-04268-6