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Deficient induction of sulfobromophthalein conjugating activity by phenobarbital in hamster liver.
- Source :
-
Biochemical pharmacology [Biochem Pharmacol] 1987 Aug 15; Vol. 36 (16), pp. 2617-20. - Publication Year :
- 1987
-
Abstract
- Administration of phenobarbital, a known inducer of glutathione S-transferase activity in rat liver, failed to stimulate sulfobromophthalein (BSP) conjugation by liver cytosol in hamsters. The latter displayed poor ability to conjugate this substrate, despite very high glutathione-conjugating activity with the broad-spectrum substrate 1-chloro-2,4-dinitrobenzene (CDNB). Of the six substrates tested, in this species, 1,2-epoxy-3-(4-nitrophenoxy)propane (ENPP) was the only one whose conjugation was greatly enhanced by phenobarbital (+172%). Nevertheless, hamsters proved as responsive to phenobarbital induction as rats, since it increased their relative liver weight and microsomal enzyme activity. The deficient induction of liver BSP-conjugating activity observed with phenobarbital is consistent with the finding that it did not affect the hepatic transport of this substrate in hamsters.
- Subjects :
- Animals
Cricetinae
Dinitrochlorobenzene metabolism
Enzyme Induction
Epoxy Compounds metabolism
Glutathione analogs & derivatives
Glutathione metabolism
Glutathione Disulfide
Glutathione Transferase biosynthesis
Liver metabolism
Male
Mesocricetus
Nitrophenols metabolism
Liver drug effects
Phenobarbital pharmacology
Sulfobromophthalein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-2952
- Volume :
- 36
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Biochemical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 3606660
- Full Text :
- https://doi.org/10.1016/0006-2952(87)90540-5