Back to Search
Start Over
Intrinsic Plasticity Mechanisms of Repetitive Transcranial Magnetic Stimulation.
- Source :
-
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [Neuroscientist] 2024 Apr; Vol. 30 (2), pp. 260-274. Date of Electronic Publication: 2022 Sep 05. - Publication Year :
- 2024
-
Abstract
- Repetitive transcranial magnetic stimulation (rTMS) has become an increasingly popular tool to modulate neural excitability and induce neural plasticity in clinical and preclinical models; however, the physiological mechanisms in which it exerts these effects remain largely unknown. To date, studies have primarily focused on characterizing rTMS-induced changes occurring at the synapse, with little attention given to changes in intrinsic membrane properties. However, accumulating evidence suggests that rTMS may induce its effects, in part, via intrinsic plasticity mechanisms, suggesting a new and potentially complementary understanding of how rTMS alters neural excitability and neural plasticity. In this review, we provide an overview of several intrinsic plasticity mechanisms before reviewing the evidence for rTMS-induced intrinsic plasticity. In addition, we discuss a select number of neurological conditions where rTMS-induced intrinsic plasticity has therapeutic potential before speculating on the temporal relationship between rTMS-induced intrinsic and synaptic plasticity.<br />Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Humans
Neuronal Plasticity physiology
Transcranial Magnetic Stimulation
Synapses
Subjects
Details
- Language :
- English
- ISSN :
- 1089-4098
- Volume :
- 30
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 36059273
- Full Text :
- https://doi.org/10.1177/10738584221118262