Back to Search
Start Over
The synthesis of novel thioderivative chalcones and their influence on NF-κB, STAT3 and NRF2 signaling pathways in colorectal cancer cells.
- Source :
-
Scientific reports [Sci Rep] 2022 Sep 01; Vol. 12 (1), pp. 14915. Date of Electronic Publication: 2022 Sep 01. - Publication Year :
- 2022
-
Abstract
- This study aimed to synthesize new thioderivative chalcones and analyze their impact on the NF-κB, STAT3, EGFR and Nrf2 signaling pathways in colorectal cancer cells. Among the studied compounds, derivatives 4 and 5 decreased the activation of NF-κB and the expression of the target gene COX-2. In the case of STAT3, we observed the inhibition of activation of this signaling pathway after influencing derivative 4. Increased activation of the Nrf2 signaling pathway was demonstrated for derivatives 5 and 7 in DLD-1 and HCT116 cells. The results of this study indicated that new chalcone derivatives, especially compounds 4, 5, and-to some degree-7, possess potential applications in the prevention of colorectal cancer.<br /> (© 2022. The Author(s).)
- Subjects :
- Humans
NF-E2-Related Factor 2 drug effects
NF-E2-Related Factor 2 metabolism
NF-kappa B drug effects
NF-kappa B metabolism
STAT3 Transcription Factor drug effects
STAT3 Transcription Factor metabolism
Chalcone chemistry
Chalcones chemistry
Chalcones pharmacology
Colorectal Neoplasms drug therapy
Colorectal Neoplasms metabolism
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 36050500
- Full Text :
- https://doi.org/10.1038/s41598-022-18981-4