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Epidemiology of carbapenem resistant Acinetobacter baumannii in New Zealand.
- Source :
-
The New Zealand medical journal [N Z Med J] 2022 Sep 02; Vol. 135 (1561), pp. 76-82. Date of Electronic Publication: 2022 Sep 02. - Publication Year :
- 2022
-
Abstract
- Aim: Carbapenem resistant Acinetobacter baumannii have limited treatment options and a propensity to cause hospital outbreaks. In recent years an increase in their detection has been observed in New Zealand. This study aimed to describe the molecular epidemiology of these isolates.<br />Method: This study utilised carbapenem resistant A. baumannii complex isolates identified across New Zealand between January 2010 to April 2018. Whole genome sequence analysis and associated demographic information was used to contextualise local isolates within the global epidemiology and establish the relationship between isolates.<br />Results: Thirty-three carbapenem resistant A. baumannii complex isolates (31 A. baumannii sensu stricto) were identified. Twenty-four (73%) were from January 2015 onwards. Twenty-four (73%) had an identifiable epidemiological link to overseas hospitalisation. Twenty-three (74%) of 31 A. baumannii sensu stricto were sequence type (ST) 2 (Pasteur scheme). Phylogenetic analysis identified three ST2 clusters. The largest cluster, of 12 isolates, was from 2015 onwards; with nine (75%) associated with recent hospitalisation in Fiji or Samoa.<br />Conclusion: Increasing numbers of carbapenem resistant A. baumannii are being identified in New Zealand. Our data show that this is in large part associated with transnational spread of a single A. baumannii sensu stricto ST 2 strain between Fiji, Samoa and New Zealand.<br />Competing Interests: Nil.<br /> (© PMA.)
- Subjects :
- Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
Bacterial Proteins
Humans
Microbial Sensitivity Tests
Molecular Epidemiology
Multilocus Sequence Typing
New Zealand epidemiology
Phylogeny
beta-Lactam Resistance
beta-Lactamases genetics
Acinetobacter Infections drug therapy
Acinetobacter Infections epidemiology
Acinetobacter baumannii genetics
Carbapenems pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1175-8716
- Volume :
- 135
- Issue :
- 1561
- Database :
- MEDLINE
- Journal :
- The New Zealand medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 36049792
- Full Text :
- https://doi.org/10.26635/6965.5783