Biological studies on indole derivatives. I. Synthesis and pharmacological studies of 2-oxo-3-indolyl derivatives.

Authors :: Khan MT
Ashraf M
Alam M
Lone KP
Source :: Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia [Acta Physiol Pharmacol Latinoam] 1986; Vol. 36 (4), pp. 391-5.
Publication Year :: 1986
Abstract: Two compounds, 3-hydroxy-3-acetonyl-oxindole (I) and compound 3-acetonylidene-oxindole (II) were synthesized by a convenient method, and their pharmacological/toxicological effects were studied in rabbit. These compounds produced transitory effects on serum enzymes. The cholesterol mobilizing effect is more prominent with compound (I).

Subjects :: Alanine Transaminase blood
Animals
Aspartate Aminotransferases blood
Blood Proteins analysis
Body Weight drug effects
Cholesterol blood
Hemoglobins analysis
Indoles administration & dosage
Injections, Intraperitoneal
Male
Oxindoles
Rabbits
Indoles pharmacology

Language :: English
ISSN :: 0326-6656
Volume :: 36
Issue :: 4
Database :: MEDLINE
Journal :: Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia
Publication Type :: Academic Journal
Accession number :: 3604703

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