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Distinct volumetric features of cerebrospinal fluid distribution in idiopathic normal-pressure hydrocephalus and Alzheimer's disease.
- Source :
-
Fluids and barriers of the CNS [Fluids Barriers CNS] 2022 Sep 01; Vol. 19 (1), pp. 66. Date of Electronic Publication: 2022 Sep 01. - Publication Year :
- 2022
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Abstract
- Objective: The aims of the study were to measure the cerebrospinal fluid (CSF) volumes in the lateral ventricle, high-convexity subarachnoid space, and Sylvian fissure region in patients with idiopathic normal-pressure hydrocephalus (INPH) and Alzheimer's disease (AD), and to evaluate differences in these volumes between INPH and AD groups and healthy controls.<br />Methods: Forty-nine INPH patients, 59 AD patients, and 26 healthy controls were imaged with automated three-dimensional volumetric MRI.<br />Results: INPH patients had larger lateral ventricles and CSF spaces of the Sylvian fissure region and smaller high-convexity subarachnoid spaces than other groups, and AD patients had larger lateral ventricles and CSF spaces of the Sylvian fissure region than the control group. The INPH group showed a negative correlation between lateral ventricle and high-convexity subarachnoid space volumes, while the AD group showed a positive correlation between lateral ventricle volume and volume for CSF spaces of the Sylvian fissure region. The ratio of lateral ventricle to high-convexity subarachnoid space volumes yielded an area under the curve of 0.990, differentiating INPH from AD.<br />Conclusions: Associations between CSF volumes suggest that there might be different mechanisms between INPH and AD to explain their respective lateral ventricular dilations. The ratio of lateral ventricle to high-convexity subarachnoid space volumes distinguishes INPH from AD with good diagnostic sensitivity and specificity. We propose to refer to this ratio as the VOSS (ventricle over subarachnoid space) index.<br /> (© 2022. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2045-8118
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Fluids and barriers of the CNS
- Publication Type :
- Academic Journal
- Accession number :
- 36045420
- Full Text :
- https://doi.org/10.1186/s12987-022-00362-8