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Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma.
- Source :
-
Autophagy [Autophagy] 2023 Apr; Vol. 19 (4), pp. 1184-1198. Date of Electronic Publication: 2022 Sep 07. - Publication Year :
- 2023
-
Abstract
- Abbreviations: cld-CASP3: cleaved caspase 3; cld-PARP: cleaved PARP; DTP: drug tolerant persister; GO: Gene Ontology; GTEx: The Genotype-Tissue Expression; HCC: hepatocellular carcinoma; HCQ: hydroxychloroquine; IC50: half maximal inhibitory concentration value; KEGG: Kyoto Encyclopedia of Genes and Genomes; LAPTM5: lysosomal protein transmembrane 5; NT: non-targeting; PDC: patient-derived primary cell lines; PDO: patient-derived primary organoid; TCGA: The Cancer Genome Atlas.
- Subjects :
- Humans
Clustered Regularly Interspaced Short Palindromic Repeats
Poly(ADP-ribose) Polymerase Inhibitors
Autophagy
Membrane Proteins genetics
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular pathology
Liver Neoplasms drug therapy
Liver Neoplasms genetics
Liver Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1554-8635
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Autophagy
- Publication Type :
- Academic Journal
- Accession number :
- 36037300
- Full Text :
- https://doi.org/10.1080/15548627.2022.2117893