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Drug hypersensitivity syndrome induced by sulfasalazine: A case report.
- Source :
-
Medicine [Medicine (Baltimore)] 2022 Aug 19; Vol. 101 (33), pp. e30060. - Publication Year :
- 2022
-
Abstract
- Introduction: Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality.<br />Patient Concerns: A 52-year-old man was hospitalized for developing a rash after 3 weeks of sulfasalazine treatment for ulcerative colitis (UC).<br />Diagnosis: The patient was diagnosed with DHS based on his drug history, clinical manifestations, and laboratory test results.<br />Interventions: The patient was administered intravenous glucocorticoids. The patient's condition improved after treatment with human immunoglobulin and antihistamines.<br />Outcomes: Combination therapy of glucocorticoid and gamma globulin, the whole-body pruritus disappeared, and no new rash appeared. The whole-body rash subsided or turned dark red.<br />Conclusion: This article describes the diagnosis and treatment process of a case of sulfasalazine-induced DHS and reviews the relevant literature to improve clinician understanding and avoid misdiagnosis and missed diagnosis.<br />Competing Interests: The authors have no conflicts of interest to disclose.<br /> (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 101
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 35984191
- Full Text :
- https://doi.org/10.1097/MD.0000000000030060