A pilot study of BW A515U (6-deoxyacyclovir) in chronic hepatitis B virus infection.

Authors :: Weller IV
Tedder RS
Karayiannis P
Thomas HC
Fiddian AP
Source :: Journal of hepatology [J Hepatol] 1986; Vol. 3 Suppl 2, pp. S119-22.
Publication Year :: 1986
Abstract: BW A515U (6-Deoxyacyclovir) is a pro-drug of acyclovir and almost 100% is absorbed orally. 250 mg orally 6-hourly for 10 days was given to 4 hepatitis B surface antigen/e antigen-positive carriers. No consistent effect on productive viral replication, as determined by serum DNA polymerase and DNA levels was observed. The changes that occurred in these markers and transaminases in 1 patient were attributed to a spontaneous depression of productive viral replication.

Subjects :: Acyclovir therapeutic use
Adult
Carrier State drug therapy
DNA, Viral blood
DNA-Directed DNA Polymerase blood
Hepatitis B virus physiology
Homosexuality
Humans
Male
Pilot Projects
Virus Replication drug effects
Acyclovir analogs & derivatives
Antiviral Agents therapeutic use
Hepatitis B drug therapy

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