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Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation.

Authors :
Rao X
Hua F
Zhang L
Lin Y
Fang P
Chen S
Ying J
Wang X
Source :
Journal of translational medicine [J Transl Med] 2022 Aug 16; Vol. 20 (1), pp. 369. Date of Electronic Publication: 2022 Aug 16.
Publication Year :
2022

Abstract

With the advent of an aging society, the incidence of dementia is increasing, resulting in a vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated in various neurological diseases with cognitive dysfunction such as Alzheimer's disease, multiple sclerosis, ischemic stroke, traumatic brain injury, and central nervous system infections. As an important neuroinflammatory factor, interleukin-33 (IL-33) is highly expressed in various tissues and cells in the mammalian brain, where it plays a role in the pathogenesis of a number of central nervous system conditions. Reams of previous studies have shown that IL-33 has both pro- and anti-inflammatory effects, playing dual roles in the progression of diseases linked to cognitive impairment by regulating the activation and polarization of immune cells, apoptosis, and synaptic plasticity. This article will summarize the current findings on the effects IL-33 exerts on cognitive function by regulating neuroinflammation, and attempt to explore possible therapeutic strategies for cognitive disorders based on the adverse and protective mechanisms of IL-33.<br /> (© 2022. The Author(s).)

Details

Language :
English
ISSN :
1479-5876
Volume :
20
Issue :
1
Database :
MEDLINE
Journal :
Journal of translational medicine
Publication Type :
Academic Journal
Accession number :
35974336
Full Text :
https://doi.org/10.1186/s12967-022-03570-w