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Perfecting antigen prediction.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2022 Sep 05; Vol. 219 (9). Date of Electronic Publication: 2022 Aug 16. - Publication Year :
- 2022
-
Abstract
- Advances in genomics and precision measurement have continued to demonstrate the importance of the immune system across many disease types. At the heart of many emerging approaches to leverage these insights for precision immunotherapies is the computational antigen prediction problem. We propose a threefold approach to improving antigen predictions: further defining the geometry of the antigen landscape, incorporating the coupling of antigen recognition to other cellular processes, and diversifying the training sets used for models that predict immunogenicity.<br /> (© 2022 Hoyos and Greenbaum.)
- Subjects :
- Immunotherapy
Antigens
Genomics
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 219
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 35972475
- Full Text :
- https://doi.org/10.1084/jem.20220846