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Heat Shock Proteins 70 Regulate Cell Motility and Invadopodia-Associated Proteins Expression in Oral Squamous Cell Carcinoma.
- Source :
-
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Jul 26; Vol. 13, pp. 890218. Date of Electronic Publication: 2022 Jul 26 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Background: Many studies have shown that diabetes is often closely related to oral squamous cell carcinoma (OSCC) occurrence and metastasis. Heat shock protein 70 (Hsp70) is a molecular chaperone related to diabetes complications. This study aims to investigate the role of Hsp70 in OSCC in expression of invadopodia-associated proteins.<br />Methods: The expressions and correlation of HSP70, Hif1α, MMP2, MMP14, and cortactin were examined using bioinformatics analysis and verified by OSCC tissue microarrays. Assay in vitro was performed to analyze cell migration capacity after treatment with or without the HSP70 inhibitor.<br />Results: The expressions of invadopodia-associated proteins were enhanced in OSCC tissues compared with paracarcinoma tissues and partially correlated with HSP70. Inhibiting HSP70 significantly decreased the cell viability, proliferation, and migration of OSCC cells.<br />Conclusions: HSP70 may be involved in invadopodia-associated proteins in OSCC cells, which provides a promising method for treatment of OSCC metastasis.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Ding, Zhang, Yang, Wu, Su and Wang.)
- Subjects :
- Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Cell Movement genetics
Cell Movement physiology
Humans
Neoplasm Metastasis genetics
Neoplasm Metastasis physiopathology
HSP70 Heat-Shock Proteins genetics
HSP70 Heat-Shock Proteins metabolism
Head and Neck Neoplasms genetics
Head and Neck Neoplasms metabolism
Head and Neck Neoplasms pathology
Mouth Neoplasms genetics
Mouth Neoplasms metabolism
Mouth Neoplasms pathology
Podosomes metabolism
Podosomes pathology
Squamous Cell Carcinoma of Head and Neck genetics
Squamous Cell Carcinoma of Head and Neck metabolism
Squamous Cell Carcinoma of Head and Neck pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-2392
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Frontiers in endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 35957827
- Full Text :
- https://doi.org/10.3389/fendo.2022.890218