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The immunoreceptor SLAMF8 promotes the differentiation of follicular dendritic cell-dependent monocytic cells with B cell-activating ability.
- Source :
-
FEBS letters [FEBS Lett] 2022 Oct; Vol. 596 (20), pp. 2659-2667. Date of Electronic Publication: 2022 Aug 19. - Publication Year :
- 2022
-
Abstract
- Follicular dendritic cells (FDCs) play a crucial role in generating high-affinity antibody-producing B cells during the germinal center (GC) reaction. Herein, we analysed the altered gene expression profile of a mouse FDC line, FL-Y, following lymphotoxin β receptor stimulation, and observed increased Slam-family member 8 (Slamf8) mRNA expression. Forced Slamf8 expression and SLAMF8-Fc addition enhanced the ability of FL-Y cells to induce FDC-induced monocytic cell (FDMC) differentiation. FDMCs accelerated GC-phenotype proliferation in cultured B cells, suggesting that they are capable of promoting GC responses. Furthermore, a pulldown assay showed that SLAMF8-Fc could bind to SLAMF8-His. Overall, the homophilic interaction of SLAMF8 promotes FDMC differentiation and SLAMF8 might act as a novel regulator of GC responses by regulating FDMC differentiation.<br /> (© 2022 Federation of European Biochemical Societies.)
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 596
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 35953458
- Full Text :
- https://doi.org/10.1002/1873-3468.14468