Back to Search
Start Over
Spatial multi-omic map of human myocardial infarction.
- Source :
-
Nature [Nature] 2022 Aug; Vol. 608 (7924), pp. 766-777. Date of Electronic Publication: 2022 Aug 10. - Publication Year :
- 2022
-
Abstract
- Myocardial infarction is a leading cause of death worldwide <superscript>1</superscript> . Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies to reduce late-stage mortality <superscript>2</superscript> . Here we generate an integrative high-resolution map of human cardiac remodelling after myocardial infarction using single-cell gene expression, chromatin accessibility and spatial transcriptomic profiling of multiple physiological zones at distinct time points in myocardium from patients with myocardial infarction and controls. Multi-modal data integration enabled us to evaluate cardiac cell-type compositions at increased resolution, yielding insights into changes of the cardiac transcriptome and epigenome through the identification of distinct tissue structures of injury, repair and remodelling. We identified and validated disease-specific cardiac cell states of major cell types and analysed them in their spatial context, evaluating their dependency on other cell types. Our data elucidate the molecular principles of human myocardial tissue organization, recapitulating a gradual cardiomyocyte and myeloid continuum following ischaemic injury. In sum, our study provides an integrative molecular map of human myocardial infarction, represents an essential reference for the field and paves the way for advanced mechanistic and therapeutic studies of cardiac disease.<br /> (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
- Subjects :
- Case-Control Studies
Chromatin genetics
Epigenome
Humans
Myocardium metabolism
Myocardium pathology
Myocytes, Cardiac metabolism
Myocytes, Cardiac pathology
Time Factors
Atrial Remodeling genetics
Chromatin Assembly and Disassembly
Gene Expression Profiling
Myocardial Infarction genetics
Myocardial Infarction pathology
Single-Cell Analysis
Ventricular Remodeling genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 608
- Issue :
- 7924
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 35948637
- Full Text :
- https://doi.org/10.1038/s41586-022-05060-x