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Associations between shortened telomeres and rheumatoid arthritis-associated interstitial lung disease among U.S. Veterans.

Authors :
Natalini JG
England BR
Baker JF
Chen Q
Singh N
Mahajan TD
Roul P
Thiele GM
Sauer BC
Mikuls TR
Johnson FB
Kawut SM
Source :
Respiratory medicine [Respir Med] 2022 Sep; Vol. 201, pp. 106943. Date of Electronic Publication: 2022 Aug 03.
Publication Year :
2022

Abstract

Background: Shortened telomeres are associated with several different subtypes of interstitial lung disease (ILD), although studies of telomere length and ILD in rheumatoid arthritis (RA) are lacking.<br />Methods: Within the Veterans Affairs Rheumatoid Arthritis (VARA) registry, we performed cross-sectional and case-control studies of prevalent and incident ILD, respectively. We randomly selected a subset of RA patients with ILD and individually matched them to RA patients without ILD according to age, sex, and VARA enrollment date. Telomere length was measured on peripheral blood leukocytes collected at registry enrollment using quantitative PCR (T/S ratio). Short telomeres were defined as a T/S ratio in the lowest 10th percentile of the cohort.<br />Results: Our cross-sectional study cohort was comprised of 54 RA-ILD patients and 92 RA-non-ILD patients. T/S ratios significantly differed between patients with and without prevalent ILD (1.56 [IQR 1.30, 1.78] vs. 1.96 [IQR 1.65, 2.27], p < 0.001). Similarly, prevalence of ILD was significantly higher in patients with short vs. normal-length telomeres (73.3% vs. 32.8%, p = 0.002). Short telomeres were independently associated with an increased odds of prevalent ILD compared to normal-length telomeres (adjusted OR 6.60, 95% CI 1.78-24.51, p = 0.005). In our case-control analysis, comprised of 22 incident RA-ILD cases and 36 RA-non-ILD controls, short telomeres were not associated with incident RA-ILD (adjusted OR 0.90, 95% CI 0.06-13.4, p = 0.94).<br />Conclusion: Short telomeres were strongly associated with prevalent but not incident ILD among patients with RA. Additional studies are needed to better understand telomere length dynamics among RA patients with and without ILD.<br />Competing Interests: Declaration of competing interest None to report. Specifically, JGN, JFB, QC, NS, TDM, PR, GMT, BCS, TRM, and FBJ and have no relevant conflicts of interest. BRE has received consulting fees from Boehringer Ingelheim unrelated to this project. SMK has received consulting fees from Acceleron Pharma, United Therapeutics Corporation, and VIVUS unrelated to this project and holds stock in AbbVie.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1532-3064
Volume :
201
Database :
MEDLINE
Journal :
Respiratory medicine
Publication Type :
Academic Journal
Accession number :
35947933
Full Text :
https://doi.org/10.1016/j.rmed.2022.106943