Ionizing radiation damage and repair from 3D-genomic perspective.

Authors :: Zheng Y
Li H
Bo X
Chen H
Source :: Trends in genetics : TIG [Trends Genet] 2023 Jan; Vol. 39 (1), pp. 1-4. Date of Electronic Publication: 2022 Aug 04.
Publication Year :: 2023
Abstract: Ionizing radiation (IR)-induced DNA damage and repair are complex and occur at hierarchical chromatin structures; radiobiology needs to be studied from a 3D-genomic perspective. Differences in IR damage and repair throughout the 3D genome may help to explain differences in radiosensitivity.<br />Competing Interests: Declaration of interests The authors declare that they have no competing interest.<br /> (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)