Cobalt(III)- and rhodium(III)-porphyrin complexes for the effective degradation of fentanyl: Biological inactivation and mechanistic insights.

Authors :: Pal H
Nina A
Nag OK
Chouinard CD
Pitt A
Ellis GA
Walper SA
Deschamps J
Burkus-Matesevac A
Maiello K
Delehanty JB
Knight DA
Source :: Journal of inorganic biochemistry [J Inorg Biochem] 2022 Oct; Vol. 235, pp. 111935. Date of Electronic Publication: 2022 Jul 18.
Publication Year :: 2022
Abstract: Cobalt(III) and rhodium(III) complexes containing the water-soluble porphyrin ligand meso-tri(4-sulfonatophenyl)mono(4-carboxyphenyl)porphine (C <subscript>1</subscript> S <subscript>3</subscript> TPP), [Rh(C <subscript>1</subscript> S <subscript>3</subscript> TPP)]Na <subscript>x</subscript> •nH <subscript>2</subscript> O (1) and [Co(C <subscript>1</subscript> S <subscript>3</subscript> TPP)]Na <subscript>x</subscript> •nH <subscript>2</subscript> O (2) were prepared from the direct reaction of free porphyrin and metal chloride salts in refluxing MeOH/DMF or EtOH/H <subscript>2</subscript> O. Compounds 1 and 2 were characterized using UV-vis and <superscript>1</superscript> H NMR spectroscopies, and high-resolution mass spectrometry. Cell culture based assays of opioid receptor activation showed that while the rhodium complex reduced fentanyl opioid activity 113-fold to an IC50 value of 1.7 μM, the cobalt complex reduced fentanyl activity by 160-fold to an IC50 value of 2.4 μM. An oxidative mechanism for fentanyl breakdown is proposed.<br /> (Copyright © 2022. Published by Elsevier Inc.)

Subjects :: Cobalt chemistry
Fentanyl pharmacology
Ligands
Porphyrins chemistry
Porphyrins pharmacology
Rhodium chemistry

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