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A Randomized Controlled Trial on the Effect of Local Insulin Glargine on Venous Ulcer Healing.
- Source :
-
The Journal of surgical research [J Surg Res] 2022 Nov; Vol. 279, pp. 657-665. Date of Electronic Publication: 2022 Aug 03. - Publication Year :
- 2022
-
Abstract
- Introduction: To determine whether the local administration of insulin glargine compared with placebo in nondiabetic patients with venous ulcers (VUs) leads to increased wound healing.<br />Methods: A randomized controlled trial using a split-plot design was performed in 36 adults with leg VUs >25 cm <superscript>2</superscript> and more than 3 mo of evolution. Each hemi-wound received either 10 UI insulin glargine or saline solution once a day for 7 d. Size of the wounds, thermal asymmetry, the number of blood vessels, and the percentage area of collagen content in wound biopsies were assessed at baseline and after 7 d of treatment. Blood capillary glucose was monitored once a day after the insulin injection.<br />Results: After 7 d of treatment, the hemi-wounds treated with insulin glargine were significantly smaller, had less thermal asymmetry, more blood vessels, and more collagen content than the saline-treated side. Correlation between thermal asymmetry and the number of blood vessels was also found (r <superscript>2</superscript>  = 66.2, P < 0.001). No patient presented capillary glucose levels ≤3.3 mmol/L nor any adverse effects.<br />Conclusions: In nondiabetic patients with chronic VUs, the topical administration of insulin glargine seems to be safe and promotes wound healing and tissue repair after 7 d of treatment.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1095-8673
- Volume :
- 279
- Database :
- MEDLINE
- Journal :
- The Journal of surgical research
- Publication Type :
- Academic Journal
- Accession number :
- 35932720
- Full Text :
- https://doi.org/10.1016/j.jss.2022.06.070