Long-term normothermic perfusion of human livers for longer than 12 days.

Authors :: Lau NS
Ly M
Dennis C
Liu K
Kench J
Crawford M
Pulitano C
Source :: Artificial organs [Artif Organs] 2022 Dec; Vol. 46 (12), pp. 2504-2510. Date of Electronic Publication: 2022 Aug 05.
Publication Year :: 2022
Abstract: In this case report, we preserved human livers for up to 13 days under normothermic conditions using a modified commercial perfusion system. Two whole livers were split into two left lateral segment grafts and two extended right grafts without interruption to blood flow and then perfused on separate machines. Not only does this provide the basis for a meaningful study of liver function in the long term, but this could also facilitate the development of a model of ex situ liver regeneration.<br /> (© 2022 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)