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IgG4-related lung disease with a desquamative interstitial pneumonia pattern radiologically and pathologically.
- Source :
-
BMJ case reports [BMJ Case Rep] 2022 Aug 01; Vol. 15 (8). Date of Electronic Publication: 2022 Aug 01. - Publication Year :
- 2022
-
Abstract
- A man in his 60s exhibited persistent dry cough and dyspnoea, which persisted even after smoking cessation. Chest high-resolution CT showed diffuse ground-glass opacities in the subpleural areas of both lungs. He underwent bronchoscopy, but no definitive diagnosis could be made. Histopathological analysis of the specimen obtained by surgical lung biopsy showed a desquamative interstitial pneumonia (DIP) pattern, with lymphocyte and plasma cell infiltrates in the alveolar septa; the ratio of IgG and IgG4-positive cells was more than 90%. He quit smoking, but the radiological findings worsened. Based on the pathological findings, we diagnosed the patient with DIP due to IgG4-related lung disease. Prednisolone was initiated, and the symptoms and radiological findings improved.<br />Competing Interests: Competing interests: None declared.<br /> (© BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Humans
Immunoglobulin G
Lung diagnostic imaging
Lung pathology
Male
Prednisolone therapeutic use
Thorax pathology
Immunoglobulin G4-Related Disease diagnosis
Immunoglobulin G4-Related Disease diagnostic imaging
Lung Diseases, Interstitial diagnostic imaging
Lung Diseases, Interstitial drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 35914802
- Full Text :
- https://doi.org/10.1136/bcr-2022-249998