Back to Search Start Over

The Relationship between Clinical Findings and Viral Load in Adenoviral Keratoconjunctivitis.

Authors :
Isik P
Harbiyeli II
Ozturk G
Erdem E
Yagmur M
Yarkin F
Source :
Japanese journal of infectious diseases [Jpn J Infect Dis] 2022 Nov 22; Vol. 75 (6), pp. 592-596. Date of Electronic Publication: 2022 Jul 29.
Publication Year :
2022

Abstract

The aim of this study was to evaluate the relationship between clinical findings and viral load in adenoviral keratoconjunctivitis (Ad-Kc). In this cross-sectional study, 30 eyes of 30 patients with Ad-Kc were assessed. Real-time polymerase chain reaction was performed to detect and quantify adenovirus in all samples. Patients were divided into three subgroups according to baseline viral load (<10 <superscript>7</superscript> , 10 <superscript>7</superscript> -10 <superscript>8</superscript> , >10 <superscript>8</superscript> human adenovirus [HAdV] copies/mL). The duration of follow-up, HAdV DNA copy number, treatment regimen, and detailed clinical findings, including uncorrected visual acuity, eyelid edema, conjunctival hyperemia, chemosis, follicular reaction, corneal involvement, conjunctival pseudomembrane, and subepithelial infiltrates (SEIs) were recorded. This study showed that a high initial viral load was associated with the development of SEIs and pseudomembrane formation (P < 0.05). The clinical findings and ocular complications of Ad-Kc were similar in the treatment groups at the final examination (P > 0.05). Our results show that a high initial viral load in Ad-Kc may be predictive of inflammatory sequelae. Determining the initial viral load in Ad-Kc may help understand the clinical course of the disease better and prevent complications.

Details

Language :
English
ISSN :
1884-2836
Volume :
75
Issue :
6
Database :
MEDLINE
Journal :
Japanese journal of infectious diseases
Publication Type :
Academic Journal
Accession number :
35908877
Full Text :
https://doi.org/10.7883/yoken.JJID.2022.210