Back to Search Start Over

Fat mass to fat-free mass ratio and its associations with clinical characteristics in asthma.

Authors :
Rugila DF
Oliveira JM
Machado FVC
Correia NS
Puzzi VC
Passos NFP
Freitas PD
Pitta F
Carvalho CRF
Furlanetto KC
Source :
Heart & lung : the journal of critical care [Heart Lung] 2022 Nov-Dec; Vol. 56, pp. 154-160. Date of Electronic Publication: 2022 Jul 28.
Publication Year :
2022

Abstract

Background: Fat mass to fat-free mass ratio (FM/FFM) assesses the combined effect of the balance between fat mass and fat-free mass.<br />Aims: to evaluate the associations beetween FM/FFM and clinical outcomes in asthma and to compare clinical characteristics between individuals with higher and lower FM/FFM.<br />Methods: 128 participants with asthma underwent anthropometric, spirometry and bioelectrical impedance assessments. Physical activity in daily life (PADL) was assessed by the Actigraph for 7 days. Daily dose of inhaled medication, steps of pharmacological treatment, Asthma Control Questionnaire, Asthma Quality of Life Questionnaire and Hospital Anxiety and Depression Scale were also assessed. Participants were classified into two groups according to the 50th percentile of reference values for FM/FFM.<br />Results: Individuals with higher FM/FFM (n=75) used higher daily doses of inhaled corticosteroids, had worse lung function and fewer steps/day when compared to those with lower FM/FFM (n=53) (P≤0.021). Associations were found between absolute values of FM/FFM with lung function (FEV <subscript>1</subscript> and FVC [liters]): R <superscript>2</superscript> =0.207 and 0.364;P<0.0001), and between the categories of lower or higher FM/FFM with steps of medication treatment (Cramer's V=0.218;P=0.016) and level of PADL (Cramer's V=0.236;P=0.009). The highest FM/FFM was a determining factor of physical inactivity (OR: 3.21;95%CI:1.17-8.78) and highest steps of pharmacological treatment (OR: 8.89;95%CI:1.23-64.08).<br />Conclusion: Higher FM/FFM is significantly associated with worse clinical characteristics in individuals with asthma, such as higher doses of inhaled corticosteroids, worse lung function and fewer steps/day. Moreover, higher FM/FFM is a determining factor of physical inactivity and the highest steps of pharmacological treatment for asthma.<br />Competing Interests: Conflict of Interest All authors have no conflict of interest to disclose.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1527-3288
Volume :
56
Database :
MEDLINE
Journal :
Heart & lung : the journal of critical care
Publication Type :
Academic Journal
Accession number :
35908350
Full Text :
https://doi.org/10.1016/j.hrtlng.2022.07.006