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Serologic and Cytokine Profiles of Children with Concurrent Cerebral Malaria and Severe Malarial Anemia Are Distinct from Other Subtypes of Severe Malaria.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2022 Jun 13; Vol. 107 (2), pp. 315-319. Date of Electronic Publication: 2022 Jun 13 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- We used a protein microarray featuring Plasmodium falciparum field variants of a merozoite surface antigen to examine malaria exposure in Malian children with different severe malaria syndromes. Unlike children with cerebral malaria alone or severe malarial anemia alone, those with concurrent cerebral malaria and severe malarial anemia had serologic responses demonstrating a broader prior parasite exposure pattern than matched controls with uncomplicated disease. Comparison of levels of malaria-related cytokines revealed that children with the concurrent phenotype had elevated levels of interleukin (IL)-6, IL-8, and IL-10. Our results suggest that the pathophysiology of this severe subtype is unique and merits further investigation.
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 107
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 35895583
- Full Text :
- https://doi.org/10.4269/ajtmh.22-0135