Back to Search
Start Over
The protective effect of pomegranate peel aqueous extract on selenite-induced cataract in rats.
- Source :
-
Journal of food biochemistry [J Food Biochem] 2022 Oct; Vol. 46 (10), pp. e14356. Date of Electronic Publication: 2022 Jul 27. - Publication Year :
- 2022
-
Abstract
- The present study was performed to evaluate the preventive effect of pomegranate peel extract on sodium-induced cataract in rats. Sprague-Dawley suckling male rats were divided into four groups: group C: rats received no treatment, group P: rats received pomegranate peel aqueous extract (PPE) orally, group Se: rats received an injection of sodium selenite, group Se + P: rats received PPE and sodium selenite concomitantly. After 4 weeks, rats were sacrificed, and their lenses were homogenized and evaluated for biochemical parameters and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In the Se group, developed cataract with significant lens opacity was observed. Other changes in enzymatic and non-enzymatic antioxidants, oxidative parameters, solubility of proteins, in NO and Ca levels and the electrophoresis pattern of proteins were observed in lenses of the Se group compared to control groups. After the preventive administration of PPE, most of these parameters were normalized due to antioxidant and anti-inflammatory activities of the extract. PRACTICAL APPLICATIONS: Cataract is one of the leading causes of vision impairment among the elderly, and surgery is the major therapeutic step taken to cure it. However, surgery has its limitations and complications. Therefore, prevention of cataract development, especially in high-risk individuals, can be better than cure. Pomegranate peel extract has a high potential to prevent cataract in these people.<br /> (© 2022 Wiley Periodicals LLC.)
- Subjects :
- Animals
Antioxidants pharmacology
Glutathione metabolism
Male
Oxidative Stress
Plant Extracts pharmacology
Rats
Rats, Sprague-Dawley
Selenious Acid adverse effects
Sodium adverse effects
Sodium Dodecyl Sulfate adverse effects
Sodium Selenite pharmacology
Cataract chemically induced
Cataract drug therapy
Cataract metabolism
Pomegranate
Subjects
Details
- Language :
- English
- ISSN :
- 1745-4514
- Volume :
- 46
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of food biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35894450
- Full Text :
- https://doi.org/10.1111/jfbc.14356