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A Review of Concurrent Chemo/Radiation, Immunotherapy, Radiation Planning, and Biomarkers for Locally Advanced Non-small Cell Lung Cancer and Their Role in the Development of ECOG-ACRIN EA5181.

Authors :
Varlotto JM
Sun Z
Ky B
Upshaw J
Fitzgerald TJ
Diehn M
Lovly C
Belani C
Oettel K
Masters G
Harkenrider M
Ross H
Ramalingam S
Pennell NA
Source :
Clinical lung cancer [Clin Lung Cancer] 2022 Nov; Vol. 23 (7), pp. 547-560. Date of Electronic Publication: 2022 Jun 30.
Publication Year :
2022

Abstract

ECOG-ACRIN EA5181 is a current prospective, randomized trial that is investigating whether the addition of concomitant durvalumab to standard chemo/radiation followed by 1 year of consolidative durvalumab results in an overall survival benefit over standard chemo/radiation alone followed by 1 year of consolidative durvalumab in patients with locally advanced, unresectable non-small cell lung cancer (NSCLC). Because multiple phase I/II trials have shown the relative safety of adding immunotherapy to chemo/radiation and due to the known synergism between chemotherapy and immunotherapy, it is hoped that concomitant durvalumab can reduce the relatively high incidence of local failure (38%-46%) as seen in recent prospective, randomized trials of standard chemo/radiation in this patient population. We will review the history of radiation for LA-NSCLC and discuss the role of induction, concurrent and consolidative chemotherapy as well as the concerns for late cardiac and pulmonary toxicities associated with treatment. Furthermore, we will review the potential role of next generation sequencing, PD-L1, ctDNA and tumor mutation burden and their possible impact on this trial.<br />Competing Interests: Disclosure None.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1938-0690
Volume :
23
Issue :
7
Database :
MEDLINE
Journal :
Clinical lung cancer
Publication Type :
Academic Journal
Accession number :
35882620
Full Text :
https://doi.org/10.1016/j.cllc.2022.06.005