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The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2.
- Source :
-
Science (New York, N.Y.) [Science] 2022 Aug 26; Vol. 377 (6609), pp. 960-966. Date of Electronic Publication: 2022 Jul 26. - Publication Year :
- 2022
-
Abstract
- Understanding the circumstances that lead to pandemics is important for their prevention. We analyzed the genomic diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early in the coronavirus disease 2019 (COVID-19) pandemic. We show that SARS-CoV-2 genomic diversity before February 2020 likely comprised only two distinct viral lineages, denoted "A" and "B." Phylodynamic rooting methods, coupled with epidemic simulations, reveal that these lineages were the result of at least two separate cross-species transmission events into humans. The first zoonotic transmission likely involved lineage B viruses around 18 November 2019 (23 October to 8 December), and the separate introduction of lineage A likely occurred within weeks of this event. These findings indicate that it is unlikely that SARS-CoV-2 circulated widely in humans before November 2019 and define the narrow window between when SARS-CoV-2 first jumped into humans and when the first cases of COVID-19 were reported. As with other coronaviruses, SARS-CoV-2 emergence likely resulted from multiple zoonotic events.
- Subjects :
- Animals
Computer Simulation
Genetic Variation
Genomics methods
Humans
Molecular Epidemiology
Phylogeny
COVID-19 epidemiology
COVID-19 transmission
COVID-19 virology
Pandemics
SARS-CoV-2 classification
SARS-CoV-2 genetics
SARS-CoV-2 isolation & purification
Viral Zoonoses epidemiology
Viral Zoonoses virology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 377
- Issue :
- 6609
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 35881005
- Full Text :
- https://doi.org/10.1126/science.abp8337