Back to Search
Start Over
Recurrence after stopping anticoagulants in women with combined oral contraceptive-associated venous thromboembolism: A systematic review and meta-analysis.
- Source :
-
British journal of haematology [Br J Haematol] 2022 Oct; Vol. 199 (1), pp. 130-142. Date of Electronic Publication: 2022 Jul 25. - Publication Year :
- 2022
-
Abstract
- The risk of recurrence after discontinuation of anticoagulation for a combined oral contraceptive (COC)-associated venous thromboembolism (VTE) is unclear. Therefore, we conducted a systematic review and meta-analysis to estimate the incidence of recurrent VTE among women with COC-associated VTE, unprovoked VTE and to compare the incidence of recurrent VTE between the two groups. The Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Embase Classic +Embase and Medline ALL to July 2020 and citations from included studies were searched. Randomized controlled trials, prospective cohort studies and meta-analyses of these study types were selected. The analysis was conducted by random-effects model. Nineteen studies were identified including 1537 women [5828 person-years (PY)] with COC-associated VTE and 1974 women (7798 PY) with unprovoked VTE. Studies were at low risk of bias. The incidence rate of VTE recurrence was 1.22/100 PY [95% confidence interval (CI) 0.92-1.62, I <superscript>2</superscript>  = 6%] in women with COC-associated VTE, 3.89/100 PY (95% CI 2.93-5.17, I <superscript>2</superscript>  = 74%) in women with unprovoked VTE and the unadjusted incidence rate ratio was 0.34 (95% CI 0.26-0.46, I <superscript>2</superscript>  = 3%). The recurrence risk in women after COC-associated VTE is low and lower than after an unprovoked VTE.<br /> (© 2022 British Society for Haematology and John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 199
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 35877546
- Full Text :
- https://doi.org/10.1111/bjh.18331