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Green natural nail polish modified with essential oils to treat onychomycosis.

Authors :: Di Vito M
Scafuro C
Mariotti M
Garzoli S
Torelli R
Zhiri A
Sanguinetti M
Bugli F
Source :: Mycoses [Mycoses] 2022 Dec; Vol. 65 (12), pp. 1127-1136. Date of Electronic Publication: 2022 Jul 31.
Publication Year :: 2022
Abstract: Background: Onychomycosis (OM) accounts for about 50% of nail disorders in industrialised countries. Essential oils (EOs), aromatic natural compounds, are known for their antimicrobial activity.<br />Objective: The aim of this work was to evaluate the antifungal efficacy of seven EOs and a commercial MIX against 10 dermatophytes responsible for OM to select the most effective ones to be included in a preventive or curative formulation based on a green natural nail polish (GNNP).<br />Methods: Micro-broth dilution tests in line with EUCAST guidelines and olfactory satisfaction test were performed to select the best natural compounds previously analysed by SPME coupled with GC-MS. The same method was used to evaluate the release over time of the active compounds present in the two modified-GNNPs made by adding the best natural compound selected (the C. citratus EO) and the MIX. Furthermore, to evaluate the preventive and curative activity of modified-GNNPs, ex vivo experiments on healthy or colonised nails were performed.<br />Results and Conclusions: Data showed that MIX-modified-GNNP had preventive activity as it inhibits the fungal growth by releasing its active ingredients for 7 days, while the OE-modified GNNP acts as a natural drug showing cytocidal activity on nails colonised by dermatophytes, but it requires two weekly applications.<br /> (© 2022 Wiley-VCH GmbH.)