Back to Search
Start Over
Prenatal exposure to bisphenol S and bisphenol A differentially affects male reproductive system in the adult offspring.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Sep; Vol. 167, pp. 113292. Date of Electronic Publication: 2022 Jul 13. - Publication Year :
- 2022
-
Abstract
- Early exposure to bisphenol may result in adverse reproductive health in later life. The use of bisphenol S (BPS) has increased considerably after bisphenol A (BPA) is regulated worldwide. However, little is known about the fetal exposure to BPS compared with BPA and its effects on the reproductive system in the adult male offspring. Here, we investigated the effects of orally administered BPS and BPA (0.4, 4.0, 40.0 μg/kg bw/d) during gestation (gD4-21) on testicular development by evaluating the sperm DNA damage & methylation and testicular functions in the 90 d Wistar rats. Male offspring prenatally exposed to BPS (0.4 μg/kg) had higher plasma testosterone than BPA and control. The testis histology reveals thickened membrane by producing a wide interstitial gap between seminiferous tubules, increased testicular inflammation, oxidative stress, TIMP-1 expression, and decreased VCAM-1 expression. BPS promotes apoptosis by up-regulating IL-6, cleaved caspases, and a spike in sperm DNA fragmentation. Prenatal BPS exposure reduces sperm motility mediated via impaired PI3K-AKT signaling and increases testicular TEX11 expression in the offspring. Exposure of the fetus to BPS interferes developmental programming of the male reproductive system in the offspring. BPS could be an equally potent endocrine disruptor affecting male reproductive functions.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Benzhydryl Compounds adverse effects
Benzhydryl Compounds metabolism
Benzhydryl Compounds pharmacology
Female
Humans
Male
Phenols adverse effects
Phenols pharmacology
Phosphatidylinositol 3-Kinases metabolism
Pregnancy
Rats
Rats, Wistar
Reproduction drug effects
Reproduction physiology
Sulfones
Testosterone analysis
Testosterone metabolism
Endocrine Disruptors adverse effects
Endocrine Disruptors metabolism
Endocrine Disruptors pharmacology
Prenatal Exposure Delayed Effects metabolism
Semen drug effects
Semen metabolism
Sperm Motility drug effects
Sperm Motility physiology
Spermatozoa drug effects
Spermatozoa metabolism
Testis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 167
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 35842007
- Full Text :
- https://doi.org/10.1016/j.fct.2022.113292