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Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity.
- Source :
-
International journal of obesity (2005) [Int J Obes (Lond)] 2022 Oct; Vol. 46 (10), pp. 1801-1807. Date of Electronic Publication: 2022 Jul 15. - Publication Year :
- 2022
-
Abstract
- Background/objectives: Patients affected by obesity and Coronavirus disease 2019, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appear to have a higher risk for intensive care (ICU) admission. A state of low-grade chronic inflammation in obesity has been suggested as one of the underlying mechanisms. We investigated whether obesity is associated with differences in new inflammatory biomarkers mid-regional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and clinical outcomes in critically ill patients with SARS-CoV-2 pneumonia.<br />Subjects/methods: A total of 105 critically ill patients with SARS-CoV-2 pneumonia were divided in patients with obesity (body mass index (BMI) ≥ 30 kg/m <superscript>2</superscript> , n = 42) and patients without obesity (BMI < 30 kg/m <superscript>2</superscript> , n = 63) and studied in a retrospective observational cohort study. MR-proADM, CT-proET-1 concentrations, and conventional markers of white blood count (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were collected during the first 7 days.<br />Results: BMI was 33.5 (32-36.1) and 26.2 (24.7-27.8) kg/m <superscript>2</superscript> in the group with and without obesity. There were no significant differences in concentrations MR-proADM, CT-proET-1, WBC, CRP, and PCT at baseline and the next 6 days between patients with and without obesity. Only MR-proADM changed significantly over time (p = 0.039). Also, BMI did not correlate with inflammatory biomarkers (MR-proADM rho = 0.150, p = 0.125, CT-proET-1 rho = 0.179, p = 0.067, WBC rho = -0.044, p = 0.654, CRP rho = 0.057, p = 0.564, PCT rho = 0.022, p = 0.842). Finally, no significant differences in time on a ventilator, ICU length of stay, and 28-day mortality between patients with or without obesity were observed.<br />Conclusions: In critically ill patients with confirmed SARS-CoV-2 pneumonia, obesity was not associated with differences in MR-proADM, and CT-proET-1, or impaired outcome.<br />Trial Registration: Netherlands Trial Register, NL8460.<br /> (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
- Subjects :
- Biomarkers blood
C-Reactive Protein analysis
Critical Care
Critical Illness
Disease Progression
Humans
Patient Admission
Procalcitonin blood
Prognosis
Retrospective Studies
Adrenomedullin blood
COVID-19 blood
COVID-19 complications
COVID-19 diagnosis
Endothelin-1 blood
Obesity complications
Peptide Fragments blood
Protein Precursors blood
SARS-CoV-2
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5497
- Volume :
- 46
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International journal of obesity (2005)
- Publication Type :
- Academic Journal
- Accession number :
- 35840771
- Full Text :
- https://doi.org/10.1038/s41366-022-01184-2