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Node foretold: Cancer cells in lymph node rewire the immune system to enable further metastases.
- Source :
-
Cancer cell [Cancer Cell] 2022 Aug 08; Vol. 40 (8), pp. 812-814. Date of Electronic Publication: 2022 Jul 14. - Publication Year :
- 2022
-
Abstract
- A Cell article reports that lymph node metastases can suppress the immune system, thereby promoting further cancer spread in mouse models; this is corroborated in patients as described in a letter in this issue of Cancer Cell. The lymph node thus actively generates a cancer-permissive environment and is an untapped target to manipulate the immune system.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Lymphatic Metastasis pathology
Mice
Lymph Nodes pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 40
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 35839779
- Full Text :
- https://doi.org/10.1016/j.ccell.2022.07.001