T helper profile in pregnant women recovered from COVID-19.

Authors :: Tartaglia E
Bordoni V
Oliva A
Vergori A
Girardi E
Antinori A
Agrati C
Liuzzi G
Source :: Journal of reproductive immunology [J Reprod Immunol] 2022 Sep; Vol. 153, pp. 103661. Date of Electronic Publication: 2022 Jul 06.
Publication Year :: 2022
Abstract: T helper (Th) cell subsets play distinct and important roles during pregnancy. This work was focused on investigating the Th and cytokine profile in pregnant women recovered from COVID-19. To this aim, the frequency of Th1, Th2, Th17 subsets and the level of associated cytokines were analysed in pregnant women recovered from COVID-19 and in matched non-pregnant women. Principal component analysis highlighted a significant impact of pregnancy on Th profile with an increase of ex-Th17 subset and a parallel decrease of Th1 population. These modulations may participate in both preserving the pregnancy and reducing the risk of severe infection.<br /> (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)