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SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies.
- Source :
-
Transplant immunology [Transpl Immunol] 2022 Oct; Vol. 74, pp. 101670. Date of Electronic Publication: 2022 Jul 11. - Publication Year :
- 2022
-
Abstract
- Background: SARS-CoV-2 vaccination is strongly recommended in kidney transplant recipients (KTR) and dialysis patients. Whether these vaccinations may trigger alloantibodies, is still debated.<br />Methods: In the current study we evaluated the effect of SARS-CoV-2 mRNA vaccines on anti-Human Leukocyte Antigen (HLA) and 60 anti-non-HLA antibody profiles in clinically stable KTR and dialysis patients. In total, we included 28 KTR, 30 patients on haemodialysis, 25 patients on peritoneal dialysis and 31 controls with a positive seroresponse 16-21 days after the first dose of either the SARS-CoV-2 mRNA BNT162b2 or mRNA-1273 vaccine. Both anti-HLA and anti-non-HLA antibodies were determined prior to vaccination and 21 to 35 days after the second vaccine dose.<br />Results: Overall, the proportion of patients with detectable anti-HLA antibodies was similar before and after vaccination (class I 14% vs. 16%, p = 0.48; class II 25% before and after vaccination). After vaccination, there was no pattern in 1) additionally detected anti-HLA antibodies, or 2) the levels of pre-existing ones. Additional anti-non-HLA antibodies were detected in 30% of the patients, ranging from 1 to 5 new anti-non-HLA antibodies per patient. However, the clinical significance of anti-non-HLA antibodies is still a matter of debate. To date, only a significant association has been found for anti-non-HLA ARHGDIB antibodies and long-term kidney graft loss. No additionally developed anti-ARHGDIB antibodies or elevated level of existing anti-ARHGDIB antibodies was observed.<br />Conclusion: The current data indicate that SARS-CoV-2 mRNA vaccination does not induce anti-HLA or anti-non-HLA antibodies, corroborating the importance of vaccinating KTR and dialysis patients.<br /> (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Subjects :
- 2019-nCoV Vaccine mRNA-1273
Antibodies, Viral
BNT162 Vaccine
COVID-19 Vaccines
Graft Rejection
HLA Antigens genetics
Histocompatibility Antigens
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Humans
RNA, Messenger
Renal Dialysis
Vaccination
rho Guanine Nucleotide Dissociation Inhibitor beta
COVID-19 prevention & control
SARS-CoV-2
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5492
- Volume :
- 74
- Database :
- MEDLINE
- Journal :
- Transplant immunology
- Publication Type :
- Academic Journal
- Accession number :
- 35835296
- Full Text :
- https://doi.org/10.1016/j.trim.2022.101670