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Histopathological Landscape of Precursor Lesions of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms.

Authors :
Biancotti R
Dal Pozzo CA
Parente P
Businello G
Angerilli V
Realdon S
Savarino EV
Farinati F
Milanetto AC
Pasquali C
Vettor R
Grillo F
Pennelli G
Luchini C
Mastracci L
Vanoli A
Milione M
Galuppini F
Fassan M
Source :
Digestive diseases (Basel, Switzerland) [Dig Dis] 2023; Vol. 41 (1), pp. 34-48. Date of Electronic Publication: 2022 Jul 11.
Publication Year :
2023

Abstract

Background: Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known.<br />Summary: This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure.<br />Key Messages: The aim of the paper was to summarize what is known about precursor lesions of gastro-entero-pancreatic neuroendocrine tumors, with the goal of providing a useful tool for future research aimed at obtaining a fuller understanding of the underlying biology and early development of these diseases.<br /> (© 2022 S. Karger AG, Basel.)

Details

Language :
English
ISSN :
1421-9875
Volume :
41
Issue :
1
Database :
MEDLINE
Journal :
Digestive diseases (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
35816999
Full Text :
https://doi.org/10.1159/000525421