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Histopathological Landscape of Precursor Lesions of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms.
- Source :
-
Digestive diseases (Basel, Switzerland) [Dig Dis] 2023; Vol. 41 (1), pp. 34-48. Date of Electronic Publication: 2022 Jul 11. - Publication Year :
- 2023
-
Abstract
- Background: Despite the important advances in research on neuroendocrine neoplasms of the gastro-entero-pancreatic tract, their precursor lesions are much less well known.<br />Summary: This review analyzes the preneoplastic neuroendocrine lesions of the gastro-entero-pancreatic tract, by adopting a coherent anatomical benchmark. In particular, the settings in which neuroendocrine precursor lesions represent well-recognized pathophysiological and morphological entities (with eventual molecular correlates) have been distinguished from the ones in which the nature of preneoplastic changes is still obscure.<br />Key Messages: The aim of the paper was to summarize what is known about precursor lesions of gastro-entero-pancreatic neuroendocrine tumors, with the goal of providing a useful tool for future research aimed at obtaining a fuller understanding of the underlying biology and early development of these diseases.<br /> (© 2022 S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 1421-9875
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Digestive diseases (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 35816999
- Full Text :
- https://doi.org/10.1159/000525421