Back to Search
Start Over
Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2022 Oct; Vol. 118, pp. 1-8. Date of Electronic Publication: 2022 Jun 16. - Publication Year :
- 2022
-
Abstract
- White matter hyperintensities (WMH), a marker of small vessel cerebrovascular disease, increase risk of developing mild cognitive impairment (MCI) and Alzheimer's disease (AD). Less is known about the extent and pattern of WMH in pre-MCI stages, such as among those with objectively-defined subtle cognitive decline (Obj-SCD). Five hundred and fifty-nine Alzheimer's Disease Neuroimaging Initiative participants (170 cognitively unimpaired [CU]; 83 Obj-SCD; 306 MCI) free of clinical dementia or stroke completed neuropsychological testing and MRI exams. ANCOVA models compared cognitive groups on regional WMH adjusting for age, sex, and apolipoprotein E (APOE) ɛ4 frequency. Compared with the CU group, those with Obj-SCD had greater temporal, occipital, and frontal WMH whereas those with MCI had higher WMH volume across all regions (p's < 0.01). No differences in WMH volume were observed between the Obj-SCD and MCI groups (p's > 0.05). Findings add to growing evidence of associations between Obj-SCD and imaging biomarkers, providing support for utility of these criteria to capture subtle cognitive changes that are biologically based.<br /> (Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 118
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 35809348
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2022.06.002