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The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 02; Vol. 23 (13). Date of Electronic Publication: 2022 Jul 02. - Publication Year :
- 2022
-
Abstract
- There is evidence that the concomitance of psoriasis and obesity may originate from the interplay between multiple genetic pathways and involve gene−gene interactions. The aim of this study was to compare the genetic background related to obesity among psoriatic patients versus healthy controls by means of a Genome-Wide Association Study (GWAS). A total of 972 psoriatic patients and a total of 5878 healthy donors were enrolled in this study. DNA samples were genotyped for over 500,000 single nucleotide polymorphisms (SNPs) using Infinium CoreExome BeadChips (Illumina, San Diego, CA, USA). Statistical analysis identified eleven signals (p < 1 × 10−5) associated with BMI across the study groups and revealed a varying effect size in each sub-cohort. Seven of the alternative alleles (rs1558902 in the FTO gene, rs696574 in the CALCRL gene, as well as rs10968110, rs4551082, rs4609724, rs9320269, and rs2338833,) are associated with increased BMI among all psoriatic patients and four (rs1556519 in the ITLN2 gene, rs12972098 in the AC003006.7 gene, rs12676670 in the PAG1 gene, and rs1321529) are associated with lower BMI. The results of our study may lead to further insights into the understanding of the pathogenesis of obesity among psoriatic patients.
- Subjects :
- Adaptor Proteins, Signal Transducing genetics
Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics
Body Mass Index
Genetic Predisposition to Disease
Genotype
Humans
Lectins genetics
Membrane Proteins genetics
Obesity genetics
Overweight genetics
Polymorphism, Single Nucleotide
Genome-Wide Association Study
Psoriasis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 23
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35806402
- Full Text :
- https://doi.org/10.3390/ijms23137396